Pharmacology of neuromuscular blocking drugs
نویسندگان
چکیده
منابع مشابه
Clinical pharmacology of neuromuscular blocking agents.
The clinical pharmacology of neuromuscular blocking agents is described. During neuromuscular blockade, succinylcholine attaches to receptors in the motor end plate and depolarizes the neuromuscular junction, making the end plate refractory to acetylcholine. The nondepolarizing relaxants have a structure similar to that of succinylcholine and bind to the same receptors. Instead of depolarizing ...
متن کاملAnaphylaxis to neuromuscular-blocking drugs: all neuromuscular-blocking drugs are not the same.
5 January 2015 I n the current issue of Anesthesiology, Reddy et al.1 report a two-hospital, retrospective, observational, cohort study confirming that anaphylaxis is more common with rocuronium and succinylcholine than with atracurium, a topic that is difficult to assess and was first highlighted in this journal in 2003.2 Although any medication can potentially cause perioperative anaphylaxis,...
متن کاملThe undesirable effects of neuromuscular blocking drugs.
Neuromuscular blocking drugs are designed to bind to the nicotinic receptor at the neuromuscular junction. However, they also interact with other acetylcholine receptors in the body. Binding to these receptors causes adverse effects that vary with the specificity for the cholinergic receptor in question. Moreover, all neuromuscular blocking drugs may cause hypersensitivity reactions. Often the ...
متن کاملAdverse effects of neuromuscular blocking drugs.
Neuromuscular blocking drugs are not as notorious for producing adverse reactions as the i.v. induction agents; nevertheless, to a varying degree they all produce unfavourable or harmful effects. The newer non-depolarizing neuromuscular blockers, atracurium and vecuronium, have been developed in an attempt to overcome the disadvantages of the earlier drugs, but although much more specific agent...
متن کاملPharmacology, selection and complications associated with neuromuscular blocking drugs in ICU patients.
Use of neuromuscular blocking (NMB) drugs in the intensive care unit (ICU) increased dramatically in the 1980s but has decreased recently [1, 2]. Currently, it is estimated that <5 percent of ICU patients receive continuous administration of NMB drugs for 24 hours or more [2]. Utilization is tempered by recognition of untoward side-effects and complications associated with prolonged administrat...
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ژورنال
عنوان ژورنال: Continuing Education in Anaesthesia Critical Care & Pain
سال: 2004
ISSN: 1743-1816
DOI: 10.1093/bjaceaccp/mkh002